The patient received a total left parotidectomy and a selective neck dissection. A case of lymphoepithelial carcinoma lec occurring in right submandibular gland of a yearold indian male is presented, wherein the lesion unveiled itself only after multiple fine needle. Lymphoepithelial carcinoma versus large cell undifferentiated. Histopathologic slides revealed lymphoepithelial carcinoma lec that stained positive for cytokeratin.
Lymphoid lesions of salivary glands lymphoid lesions of salivary glands. In pathology, lymphoepithelial lesion refers to a discrete abnormality that consists of lymphoid cells and epithelium, which may or may not be benign it may refer to a benign lymphoepithelial lesion of the parotid gland or benign lymphoepithelial lesion of the lacrimal gland, or may refer to the infiltration of malignant lymphoid cells into epithelium, in the context of primary. Epsteinbarrpositive lymphoepithelial carcinoma and epi. Lymphoepithelioma is a type of poorly differentiated nasopharyngeal carcinoma characterized by prominent infiltration of lymphocytes in the area involved by tumor. The patient was disease free for four years then she had primary lung recurrence which was surgically resected. Lymphoepithelioma is also known as class iii nasopharyngeal carcinoma in the who classification system.
Nov 25, 2017 lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. May 21, 2012 this is a case of metastatic lung cancer of the lymphoepithelial like carcinoma lelc variant who first presented with symptomatic brain metastasis. Lymphoepithelioma of the mesenchymal tissue is exceedingly rare. In this case report, we discuss its etiopathogeny, its epidemiological, clinical. In western countries, salivary gland lymphoepithelial like carcinomas are uncommon and only 14 cases have been described so far. Lymphoepithelial carcinoma arising from the maxillary antrum. Benign and malignant lymphoid lesions of the salivary glands. Histologically, it is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. Metastatic squamous cell carcinoma cancer survivors network. The world health organization who has defined it as a poorly differentiated squamous cell carcinoma or histologically undifferentiated carcinoma accompanied by a prominent reactive lymphoplasmacytic infiltrate, morphologically similar to nasopharyngeal carcinoma. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Lymphoepitheliomalike carcinoma of the skin presents as a slow growing, nonpigmented nodule with similar clini cal appearance to dermatofibrosarcoma protuberans.
Avoiding underdiagnosis, overdiagnosis, and misdiagnosis. It has a high tendency to metastasize and is responsive to radiotherapy. Skin nonmelanocytic tumors lymphoepitheliomalike carcinoma. Well circumscribed lobules, nests or small aggregates of large, cohesive, epithelioid cells closely associated with a dense, mixed t and b lymphocytic and plasmacytic infiltrate rare tumors 20. Lymphoepithelial carcinoma a prominent lymphocytic infiltrate is a constant finding in lymphoepithelial carcinoma, sometimes confusingly called malignant lymphoepithelial lesion. Computed tomographic scan revealed a mass in the superficial lobe of the left parotid gland with leftsided cervical lymphadenopathy. This is a case of metastatic lung cancer of the lymphoepithelial like carcinoma lelc variant who first presented with symptomatic brain metastasis.
Ebv causes lymphoepitheliomalike lung cancer lymphoeptheliomalike carcinomas are associated with epsteinbarr virus infection, particularly in asian countries. Case report epsteinbarr virus associated lymphoepithelial. Mleacc is defined as malignant lymphoepithelial lesion with anaplastic carcinomatous change very rarely. Benign lymphoepithelial lesion a lesion of the salivary gland. In this report, we summarized the clinicopathologic features of 5 cases of lymphoepitheliomalike carcinoma of the prostate, a rare variant of prostate cancer characterized by a malignant epithelial component densely infiltrated by lymphoid cells. Who gets lymphoepithelial carcinoma of salivary gland. However, the clinician is occasionally confronted with this condition, whose early recognition and prompt irradiation are essential for a cure. Vascular endothelial cell participation in formation of lymphoepithelial lesions epimyoepithelial islands in lymphoepithelial sialadenitis benign lymphoepithelial lesion. Primary lymphoepitheliomalike carcinoma of the prostate gland plelcp is rare with hardly any information on its diagnostic features and biological behaviour.
Primary lymphoepithelial carcinoma of the parotid gland is a rare tumor with an increased incidence among eskimos and orientals. Paraneoplastic cerebellar degeneration pcd is a classical tumorassociated, immunemediated disease typically associated with gynecological malignancies, smallcell lungcancer or lymphoma. Adjunct professor, university of utah school of medicine. Lymphoepitheliomalike carcinoma llc of the stomach is a rare and peculiar type of gastric carcinoma that was first described by watanabe et al in 1976 as gastric carcinoma with a lymphoid stroma 1, 2. Mleacc malignant lymphoepithelial lesion with anaplastic carcinomatous change. This complex occurs as a circumferential cluster of discrete tonsil like aggregations of lymphoid tissues, together with epithelial ducts crypts and occasional mucus secretory units in the extreme lower portion of the. Lymphoepithelial like carcinomas lelc of the head and neck represent malignant neoplasms that are histologically similar to nasopharyngeal carcinoma npc, nonkeratinizing undifferentiated type but arise in locations other than the nasopharynx. How is malignant lymphoepithelial lesion with anaplastic carcinomatous change abbreviated. Lymphoepithelial carcinoma of the orbit in our hospital, a one patient had 75 years old male and from morocco was referred for us for realized the exophthalmia, conjunctival. Lymphoepitheliomalike carcinoma of the prostate request pdf. Lymphoepitheliomalike carcinoma lelc is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue or in cells that display epithelial characteristics that bear microscopic resemblance to lymphoepithelioma nasopharyngeal carcinoma. Butnor 2008 avoiding underdiagnosis, overdiagnosis, and misdiagnosis of lung carcinoma. Margaret theresa, post graduate student, karpaga vinayaga institute of medical sciences, madhuranthagam, during the academic year 2015 2018.
The histogenesis of lelcs remains controversial as to whether it has adnexal origin or represents an inflamed squamous cell carcinoma scc. Ebv infects 90% of the total population and there is no vaccine available longnecker, kieff and cohen 20. Paraneoplastic cerebellar degeneration associated with. Jun 23, 2011 lymphoepithelial carcinoma lec is a rare malignancy. Which statement about lymphoepitheliomalike carcinoma of the urinary tract is false. This is a case of metastatic lung cancer of the lymphoepitheliallike carcinoma lelc variant who first presented with symptomatic brain metastasis. Oct 17, 20 this is the first published case of a lymphoepithelial carcinoma associated with pcd. Our first case is a 30yearold man with lec in the left maxillary sinus. Lymphoepithelial carcinoma is an equally rare malignant neoplasia and accounts for approximately 0.
Pdf lymphoepithelial carcinoma of the submandibular gland. Lymphoepitheliomalike carcinoma of the skin lelcs is a very rare primary skin neoplasm that most frequently occurs on the sunexposed skin of the head and neck in elderly individuals. Cytokeratin positive derived from the kidney parenchyma gata3 is expressed not associated with epsteinbarr virus in contrast to nasopharyngeal carcinoma. Benign lymphoepithelial lesion wikipedia republished wiki 2. Herein, we report two cases of lec in the head and neck region that presented to oulu university hospital. A lymphoepithelial lesion is a gastrointestinal crypt with a monomorphous population of lymphocytes. Benign lymphoepithelial lesion wikipedia republished. Rationale lymphoepithelial carcinoma lec is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration. Lymphoepithelial carcinoma lec, also called lymphoepitheliomalike carcinoma, is defined as an undifferentiated carcinoma or poorly differentiated squamous cell carcinoma, accompanied by a prominent reactive lymphoplasmacytic infiltrate. Lymphoepithelial sialadenitis and sjogren syndrome are not curable but are often controllable with antiinflammatory therapies, such as corticosteroids. Apr 08, 2015 lymphocytic parotid gland enlargement in the hiv infection can be classified into three categories. There is a predilection for gender with 6080% being female.
Lymphoepitheliallike carcinoma of the parotid gland. Lymphoepitheliomalike carcinoma pathology dermnet nz. Plelcp is extremely rare and there are hardly any pictures of the tumour involving the. Lymphoepithelioma definition of lymphoepithelioma by.
In 1921 reverchon and coutard reported from regauds clinic a. The patient underwent local and systemic treatment for metastatic disease with good clinical outcome. The treatment for lymphoepithelial carcinoma of salivary gland involves a combination of surgery, chemotherapy, and radiation therapy, in most cases. Lymphoepitheliallike carcinomas of the head and neck. Although clinically significant because of its malignant nature, it is difficult to make a differential diagnosis by preoperative imaging. Lymphoepitheliomalike carcinoma, abbreviated lelc, is a rare, poorly differentiated, malignant epithelial tumour it can be considered a subtype of squamous carcinoma aka squamous cell carcinoma. Malignant lymphoepithelial lesion how is malignant lymphoepithelial lesion abbreviated. Benign lymphoid hyperplasia of the tongue masquerading as. Lymphoepithelial medical definition merriamwebster. Microscopy showed typical histologic features of multiple germinal centers with a. Metwaly h, cheng j, idayonemochi h, ohshiro k, jen ky, liu ar, saku t. Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands article in cancer 1019. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma.
Certificate certified that this dissertation entitled histomorphological patterns of salivary gland tumors is a bona fide work done by dr. A complex of lymphoepithelial organs, the anal tonsils, is a consistent structure in the anal canal of the bottlenose dolphin, tursiops truncatus. Mleacc stands for malignant lymphoepithelial lesion with anaplastic carcinomatous change. Ebv infection in childhood is generally asymptomatic. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. New case of an exceedingly rare primary skin tumor nebojsa arsenovic dermatology online journal 14 8. It is associated with lymphoid infiltration of salivary gland tissue, producing atrophy and destruction of the acini myoepithelial sialadenitis of the salivary gland is associated with an increased risk of lymphoma, but criteria that predict its development have not been. Pathology outlines lymphoepitheliomalike carcinoma. This turnout typically occurs among eskimos and chinese, and.
Primary lymphoepitheliomalike carcinoma of the prostate. The presented study summaries the literature controversies in the treatment of lec and present a case of a rare lec diagnosed in the sublingual gland of an otherwise healthy 21yearold arab woman. It constitutes about 4% of all gastric carcinomas 3, 4. It should not be confused with the benign lymphoepithelial lesion of the salivary gland. Lymphoepithelial carcinoma definition of lymphoepithelial. Sari1, omer gunhan2, sefik hosal3, mustafa cengiz 1, murat gurkaynak 1 hacettepe university faculty of medicine, department of radiation oncology 2 gulhane military medical academy and faculty of medicine, department of pathology. Please tell us where you read or heard it including the quote, if possible. The prognosis of the individual depends upon a set of several factors including the tumor stage and overall health of the individual.
An ill defined heterogeneously enhancing soft tissue attenuation lesion measuring approx 3. Lymphoepitheliomalike carcinoma vs inflamed squamous cell. Lymphoepithelial carcinoma lec is a rare malignancy. Epithelial cell infection by epsteinbarr virus fems. Controversies exist in the current literature regarding the treatment of lymphoepithelial carcinoma lec. Here we present the case of a 38year old male with an over 12 months rapidly progressive cerebellar syndrome. Morphology of complex lymphoepithelial organs of the anal. Lymphoepithelial medical definition merriamwebster medical. Jul 15, 20 primary lymphoepithelial like carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. Malignant lymphoepithelial lesion how is malignant. Lymphocytic parotid gland enlargement in the hiv infection can be classified into three categories. Lec can occur in many organs, but is most common in head and neck regions including pharynx.
Pdf lymphoepithelial carcinoma of the salivary glands. Therefore, it must be known by clinicians, pathologists and oncologists. Lymphoepitheliomalike carcinoma of the skin lelcs is a very rare, primary skin neoplasm of uncertain origin. Benign lymphoepithelial lesion is most likely to occur in adults around 50 years of age. The diagnosis of a collision tumor requires that the 2 tumors be histologically distinct. It is also more common in asian countries than in western countries. In these populations, it is usually associated with epsteinbarr virus. Two subsets of gastric cancer, epsteinbarr virus ebvpositive and microsatellite instability msihigh cancers, have been. Lymphoepitheliallike carcinomas of the head and neck are histologically similar to nasopharyngeal carcinoma nonkeratinizing undifferentiated type but by definition arise in mucosal sites other than the nasopharynx. This phenomenon has been described mostly at the esophagogastric junction, where a squamous cell carcinoma of esophageal origin collides with a gastric adenocarcinoma.